Principal Clinical Scientist

Indianapolis

**Principal Clinical Scientist (AI Training)** **About The Role** What if your career-long expertise in clinical trial design and regulatory science could directly shape how AI understands and reasons about medical evidence? We're looking for a Principal Clinical Scientist to bring senior-level rigor to frontier AI research --- ensuring the clinical data and analyses powering next-generation AI systems meet the same exacting standards expected in real-world regulatory submissions. This is a fully remote, flexible contract role built for experienced clinical scientists who want to contribute to something genuinely new. No AI background required --- just deep command of clinical research and a sharp eye for scientific quality. * Organization: Alignerr * Type: Hourly Contract * Location: Remote * Commitment: 10--40 hours/week **What You'll Do** * Design and critically review clinical trial protocols used to generate high-quality, regulatory-grade datasets for AI training * Interpret and audit clinical trial results for accuracy, consistency, and alignment with regulatory expectations * Evaluate AI-generated clinical analyses for scientific soundness and methodological integrity * Provide structured expert feedback that directly improves how AI models reason about clinical evidence, outcomes, and trial data * Work independently and asynchronously --- fully on your own schedule **Who You Are** * Senior-level experience designing clinical trial protocols intended for regulatory submission * Deep expertise interpreting clinical data for agencies such as the FDA, EMA, or equivalent global bodies * Strong grounding in clinical research methodology, biostatistics, or translational science * Naturally detail-oriented with a rigorous, systematic approach to evaluating scientific quality * Clear and precise written communicator --- able to document findings and feedback with authority * No prior AI or tech experience required **Nice to Have** * Prior involvement in data annotation, data quality assurance, or evaluation systems * Experience reviewing or contributing to clinical evidence packages for drug, device, or diagnostic submissions * Background spanning multiple therapeutic areas or trial phases * Familiarity with AI-generated content or model evaluation workflows **Why Join Us** * Work directly on frontier AI systems with real impact on clinical and biomedical research * Fully remote and flexible --- work when and where it suits you * Freelance autonomy with the structure of meaningful, expert-level work * Influence how AI understands, evaluates, and communicates real-world clinical evidence * Potential for ongoing work and contract extension as new projects launch