Principal Clinical Scientist

Denver

**Principal Clinical Scientist (AI Training)** **About The Role** What if your years of clinical research expertise could directly influence how AI understands and evaluates medical evidence for millions of people worldwide? We're looking for a Principal Clinical Scientist to bring senior-level rigor to AI-driven research workflows --- ensuring that the clinical reasoning embedded in next-generation AI systems meets the standards that matter most in real-world medicine. This is a fully remote, flexible contract role designed for experienced clinical scientists who want to work at the frontier of biomedical AI without leaving their domain expertise behind. * Organization: Alignerr * Type: Hourly Contract * Location: Remote * Commitment: 10--40 hours/week **What You'll Do** * Design and critically review clinical trial protocols used to generate high-quality, regulatory-grade datasets for AI training * Interpret and audit clinical trial results, ensuring accuracy, consistency, and alignment with regulatory expectations (FDA, EMA, or equivalent) * Evaluate AI-generated clinical analyses for scientific soundness and methodological rigor * Provide expert, structured feedback that directly shapes how AI models reason about clinical trial data, outcomes, and evidence * Flag gaps, errors, or inconsistencies in AI outputs from a senior clinical science perspective * Work independently and asynchronously --- fully on your own schedule **Who You Are** * Senior-level experience designing clinical trial protocols for regulatory submission * Deep expertise interpreting clinical data for major regulatory agencies (FDA, EMA, or equivalent) * Strong grounding in clinical research methodology, biostatistics, or translational science * Meticulous and rigorous --- you hold AI-generated content to the same standards you'd apply in a real submission * Clear, concise written communicator who can articulate expert feedback effectively * Self-directed and reliable when working independently **Nice to Have** * Prior experience with data annotation, data quality review, or evaluation systems * Familiarity with AI tools or clinical data platforms * Background spanning oncology, rare disease, cardiovascular, or other regulated therapeutic areas * Experience in translational research or early-phase clinical development **Why Join Us** * Work directly on frontier AI systems that are reshaping clinical and biomedical research * Influence how AI understands, evaluates, and reasons about real-world clinical evidence * Fully remote and flexible --- work when and where it suits you * Freelance autonomy with the structure of meaningful, high-impact expert work * Collaborate with world-leading AI research teams and labs * Potential for ongoing work and contract extension as new projects launch