Principal Clinical Scientist

New York

**Principal Clinical Scientist (AI Training)** **About The Role** What if your years of clinical trial expertise could directly shape how AI reasons about medical evidence, regulatory submissions, and patient outcomes? We're looking for a Principal Clinical Scientist to bring senior-level rigor to cutting-edge AI research --- ensuring the clinical data and analyses powering next-generation AI systems meet the standards expected in real-world regulatory environments. This is a fully remote, flexible contract role built for experienced clinical scientists who want to work at the intersection of medicine and frontier technology. No AI background needed --- just deep expertise in clinical research and regulatory science. * Organization: Alignerr * Type: Hourly Contract * Location: Remote * Commitment: 10--40 hours/week **What You'll Do** * Design and review clinical trial protocols used to generate high-quality, regulator-ready training datasets for AI systems * Interpret and audit clinical trial results to ensure accuracy, consistency, and regulatory relevance * Evaluate AI-generated clinical analyses for scientific soundness and alignment with FDA, EMA, or equivalent regulatory expectations * Provide expert, structured feedback that directly improves how AI models reason about clinical trial data, endpoints, and outcomes * Work independently and asynchronously --- fully on your own schedule **Who You Are** * Senior-level experience designing clinical trial protocols for regulatory submission * Deep expertise interpreting clinical data for agencies such as the FDA, EMA, or equivalent regulatory bodies * Strong background in clinical research methodology, biostatistics, or translational science * Naturally detail-oriented with a systematic, rigorous approach to scientific evaluation * Clear and precise written communicator comfortable providing structured, actionable feedback **Nice to Have** * Prior experience with data annotation, data quality assurance, or evaluation systems * Familiarity with AI tools or machine learning workflows in clinical or biomedical contexts * Background in pharmacovigilance, medical affairs, or health technology assessment * Experience working across multiple therapeutic areas or global regulatory jurisdictions **Why Join Us** * Work directly on frontier AI systems making a real impact on clinical and biomedical research * Fully remote and flexible --- work when and where it suits you * Freelance autonomy with the structure of meaningful, high-stakes scientific work * Influence how AI understands, evaluates, and communicates real-world clinical evidence * Collaborate with leading AI research teams and labs at the cutting edge of the field * Potential for ongoing work and contract extension as new projects launch