Principal Clinical Scientist

Chicago

**Principal Clinical Scientist (AI Training)** **About The Role** What if your career designing rigorous clinical trials and interpreting regulatory-grade data could directly influence how AI understands medicine? We're looking for a Principal Clinical Scientist to bring senior-level clinical expertise into the development of cutting-edge AI systems --- helping ensure these models reason about clinical evidence the way a seasoned scientist would. This is a fully remote, flexible contract role built for experienced clinical researchers who want to work at the intersection of science and frontier AI. No AI background required --- just deep clinical expertise and a sharp eye for scientific rigor. * Organization: Alignerr * Type: Hourly Contract * Location: Remote * Commitment: 10--40 hours/week **What You'll Do** * Design and review clinical trial protocols used to generate high-quality, regulator-ready datasets for AI training and evaluation * Interpret and audit clinical trial results to ensure accuracy, consistency, and alignment with regulatory standards * Evaluate AI-generated clinical analyses for scientific soundness and compliance with FDA, EMA, or equivalent agency expectations * Provide expert feedback that directly shapes how AI models understand, reason about, and evaluate clinical trial data and outcomes * Flag gaps in methodology, data quality, or regulatory relevance across AI-generated clinical content **Who You Are** * Senior-level clinical researcher with hands-on experience designing trial protocols for regulatory submission * Deep expertise interpreting clinical data for agencies such as the FDA, EMA, or equivalent regulatory bodies * Strong grounding in clinical research methodology, biostatistics, or translational science * Naturally rigorous --- you hold AI-generated outputs to the same standard you'd apply in a real submission * Self-directed and comfortable working independently in an asynchronous environment **Nice to Have** * Prior experience with data annotation, data quality evaluation, or AI output assessment * Background in pharmacology, oncology, rare disease, or another specialized therapeutic area * Familiarity with ICH guidelines, GCP standards, or regulatory submission frameworks * Experience working across multidisciplinary research teams **Why Join Us** * Work directly on frontier AI systems that are reshaping how clinical and biomedical research is conducted * Influence how AI understands and evaluates real-world clinical evidence --- at a scale no individual trial could achieve * Fully remote and flexible --- work when and where it suits you * Freelance autonomy with the structure of meaningful, high-impact, task-based work * Collaborate with world-leading AI research labs on problems that matter * Potential for ongoing work and contract extension as new projects launch